Papadaki L
Fertil Steril. 1978 Mar;29(3):342-50. doi: 10.1016/s0015-0282(16)43164-x.
The human ovary may contain binovular or polyovular follicles at birth, but they are unusual later in life. Binbovular follicles were found in bilateral ovarian biopsies from a patient with primary amenorrhea who had been treated with exogenous gonadotropins. The fine structural morphology of these follicles has shown that both oocytes were in the resting meiotic prophase, that their respective vitelline bodies faced each other across the intervening plasma membranes, and that the adjacent oocytes made mutual contacts similar to those found between granulosa cells and oocytes. From the appearance of the multivesicular bodies in nearby stromal fibroblasts it is suggested that these follicles had formed by fusion of two adjacent primordial follicles by a mechanism similar to the depolymerization of the ground substance in the apex of the Graafian follicle that leads to ovulation.
人类卵巢在出生时可能含有双卵或多卵卵泡，但在生命后期则较为罕见。在一名接受外源性促性腺激素治疗的原发性闭经患者的双侧卵巢活检中发现了双卵卵泡。这些卵泡的精细结构形态表明，两个卵母细胞均处于减数分裂前期的静止期，它们各自的卵黄体隔着中间的质膜相对，相邻的卵母细胞相互接触，类似于在颗粒细胞和卵母细胞之间发现的接触。从附近基质成纤维细胞中多泡体的外观来看，提示这些卵泡是由两个相邻的原始卵泡通过类似于导致排卵的格拉夫卵泡顶端基质解聚的机制融合而成的。
