Sugar A, Bokosky J E, Meyer R F
Cornea. 1984;3(4):268-71.
A prospective randomized trial evaluating the effect of topical 1% prednisolone acetate on epithelial defects after keratoplasty in 39 patients (18 in the untreated group and 21 in the treated group) failed to reveal any significant differences in healing between the two groups (p less than 0.16 to p less than 0.54 on post-operative days 1-5). The mean time needed for complete healing was 1.94 days in the untreated group and 2.81 days in the steroid treated group (p less than 0.09). Patients given subconjunctival methylprednisolone sodium succinate had larger initial defects (mean 33.5 mm2) than those not given subconjunctival steroids (mean 16.1 mm2), but the time for complete epithelial healing did not differ significantly (2.75 days vs. 1.91 days; p less than 0.14). As clinically used post-keratoplasty topical steroids do not appear to significantly delay epithelial healing in most patients.
一项前瞻性随机试验评估了局部使用1%醋酸泼尼松龙对39例角膜移植术后上皮缺损的影响（未治疗组18例，治疗组21例），结果显示两组在愈合方面未发现任何显著差异（术后1 - 5天，p值在小于0.16至小于0.54之间）。未治疗组完全愈合所需的平均时间为1.94天，类固醇治疗组为2.81天（p值小于0.09）。接受结膜下注射琥珀酸钠甲泼尼龙的患者初始缺损面积更大（平均33.5平方毫米），大于未接受结膜下类固醇注射的患者（平均16.1平方毫米），但完全上皮愈合时间无显著差异（分别为2.75天和1.91天；p值小于0.14）。临床上角膜移植术后使用的局部类固醇似乎在大多数患者中不会显著延迟上皮愈合。
