De Benedictis G, Di Maio E, Dragone A, Brancati C, Tagarelli A
Department of Cell Biology, University of Calabria, Arcavacata, Italy.
Exp Clin Immunogenet. 1984;1(4):223-31.
This paper presents data on a human allotypic polymorphism carried on a low density lipoprotein (As-LDL). The As polymorphism was investigated by a rabbit antiserum which was firstly used to analyze the serum level and the isoelectric point of the As lipoprotein in sera of different phenotype. This antiserum was also used to purify As-LDL by immunochromatography. Afterwards the peptidic maps of the APO proteins from different As-LDL were compared. While no correlation did result between the serum level and the serological phenotype of the As lipoprotein, the peptidic distribution of the APO parts from different As-LDL showed differences correlated to the allotypic phenotype.
本文展示了关于低密度脂蛋白（As-LDL）上携带的一种人类同种异型多态性的数据。通过兔抗血清研究As多态性，该抗血清首先用于分析不同表型血清中As脂蛋白的血清水平和等电点。此抗血清还用于通过免疫色谱法纯化As-LDL。之后比较了来自不同As-LDL的载脂蛋白（APO）蛋白的肽图谱。虽然As脂蛋白的血清水平与血清学表型之间未发现相关性，但来自不同As-LDL的APO部分的肽分布显示出与同种异型表型相关的差异。
