de Benedictis G, Dragone A, Brancati C, Tagarelli A
Immunol Lett. 1983 Feb;6(2):73-9. doi: 10.1016/0165-2478(83)90084-6.
This paper presents data on the identification of an allotypic polymorphism carried on a beta-lipoprotein in human serum. The antigen, whose inheritance is investigated in 78 families, is coded by a polymorphic locus (As) existing in 4 allelic states. The products of these alleles exhibit a serological linear subtyping pattern with respect to the alloantisera recognizing the allotypes. The allelic frequencies prove different in healthy (beta beta) and thalassemic (beta beta thal) sample populations, thus suggesting linkage dysequilibrium between the recessive alleles of the As and beta loci.
本文提供了关于人血清中β-脂蛋白上携带的一种同种异型多态性鉴定的数据。该抗原在78个家系中进行了遗传研究，由一个存在4种等位基因状态的多态性位点（As）编码。这些等位基因的产物相对于识别同种异型的同种抗血清呈现出血清学线性亚型模式。等位基因频率在健康（ββ）和地中海贫血（ββthal）样本群体中证明是不同的，因此表明As和β位点的隐性等位基因之间存在连锁不平衡。
