Dasta J F, Jacobi J, Wu L S, Sokoloski T, Beckley P, Reilley T E, Howie M B
Crit Care Med. 1983 Jan;11(1):50-2. doi: 10.1097/00003246-198301000-00013.
An in vitro model of a cardiopulmonary bypass (CPB) circuit using a bubble oxygenator was developed to assess the potential of this system to extract nitroglycerin (NTG). A NTG solution (100 ng/ml) was circulated through a CPB circuit at 5 L/min for 60 min. Samples obtained for NTG analysis revealed a significant loss of drug to the circuit. By 60 min, only 18% of the initial NTG concentration was present. In a separate experiment, the bubble oxygenator was shown to be the major source of drug extraction because less than 15% of the drug concentration infused directly into the oxygenator appeared in the arterial outlet. These results indicate that patients may not receive the expected dose of NTG during CPB even if caution is taken to administer the drug through nonadsorbing iv tubing.
开发了一种使用鼓泡式氧合器的体外心肺转流（CPB）回路模型，以评估该系统提取硝酸甘油（NTG）的可能性。将NTG溶液（100 ng/ml）以5 L/分钟的流速在CPB回路中循环60分钟。采集用于NTG分析的样本显示，药物在回路中有显著损失。到60分钟时，仅存在初始NTG浓度的18%。在另一项实验中，鼓泡式氧合器被证明是药物提取的主要来源，因为直接注入氧合器的药物浓度中，只有不到15%出现在动脉出口。这些结果表明，即使小心地通过非吸附性静脉输液管给药，患者在CPB期间可能也无法获得预期剂量的NTG。
