Alexander C M, Lum S M, Rhodes J, Boarman C, Nicoloff J T, Kumar D
J Clin Endocrinol Metab. 1983 Feb;56(2):279-82. doi: 10.1210/jcem-56-2-279.
Plasma fibronectin and serum thyroid parameters were determined in 6 hyperglycemic nonketoacidotic patients (HNK) and 12 subjects with diabetic ketoacidosis (DKA). The DKA patients showed a marked increase in both plasma fibronectin and serum T3 over 5 days of insulin treatment [175.2 +/- 18.1% (+/- SEM) and 208.7 +/- 17.6% of initial values respectively], while these parameters did not change in the HNK patients despite equivalent control of diabetes. Serum rT3 levels declined, as expected, to 65.8 +/- 10.9% of the initial values in the DKA patients, but did not change in the HNK patients. There was a significant positive correlation between changes in plasma fibronectin and serum T3 values in the DKA patients (r = 0.5; P less than 0.005). Other reports have shown a decrease in plasma fibronectin concentrations in fasted patients, a well known low T3 state; therefore, the association between changes in plasma fibronectin and serum T3 values may be a widely observed phenomenon. The parallel changes in fibronectin and T3 may reflect alterations in the metabolic state of these patients. The precise nature of the relationship between changes in fibronectin and T3 concentrations requires additional investigations.
对6例高血糖非酮症酸中毒患者（HNK）和12例糖尿病酮症酸中毒患者（DKA）测定了血浆纤连蛋白和血清甲状腺参数。DKA患者在胰岛素治疗的5天中血浆纤连蛋白和血清T3均显著升高[分别为初始值的175.2±18.1%（±标准误）和208.7±17.6%]，而HNK患者尽管糖尿病得到了同等控制，这些参数却未发生变化。正如预期的那样，DKA患者血清反T3水平下降至初始值的65.8±10.9%，但HNK患者血清反T3水平未发生变化。DKA患者血浆纤连蛋白变化与血清T3值之间存在显著正相关（r = 0.5；P<0.005）。其他报告显示，在禁食患者（一种众所周知的低T3状态）中血浆纤连蛋白浓度降低；因此，血浆纤连蛋白变化与血清T3值之间的关联可能是一种广泛观察到的现象。纤连蛋白和T3的平行变化可能反映了这些患者代谢状态的改变。纤连蛋白变化与T3浓度之间关系的确切性质需要进一步研究。
