Schmitz O, Laurberg P, Weeke J
Diabete Metab. 1980 Mar;6(1):51-3.
Serum T3, rT3, T4 and TSH were measured in ten healthy subjects, in nine juvenile diabetic outpatients in fair metabolic control (fasting plasma glucose 6.5 mmol/1, 2.6-9.5 mmol/1 (mean, range), HbA1 10.1%, 8.1-12.2%), and in ten juvenile diabetic outpatients in poor metabolic control but without ketonuria (fasting blood glucose 15.1 mmol/l, 11.1-22.4 mmol/l, HbA1, 13,8% 10.8-16,2%. Serum T3 was identical in normal subjects and in diabetics in fair metabolic control. Diabetics in poor metabolic control had 13.0% lower serum T3 than normal subjects (2 p less than 0.05). No difference between groups was observed in serum rT3, T4 and TSH. These findings indicate that in diabetic patients, metabolic derangement induces alterations in serum T3 more easily than in serum rT3. However, alteration in serum T3 is not a sensitive indicator of moderate metabolic derangement in diabetic patients.
对10名健康受试者、9名代谢控制良好的青少年糖尿病门诊患者（空腹血糖6.5 mmol/L，2.6 - 9.5 mmol/L（均值，范围），糖化血红蛋白10.1%，8.1 - 12.2%）以及10名代谢控制不佳但无酮尿症的青少年糖尿病门诊患者（空腹血糖15.1 mmol/L，11.1 - 22.4 mmol/L，糖化血红蛋白13.8%，10.8 - 16.2%）测定了血清三碘甲状腺原氨酸（T3）、反三碘甲状腺原氨酸（rT3）、甲状腺素（T4）和促甲状腺激素（TSH）。正常受试者和代谢控制良好的糖尿病患者的血清T3水平相同。代谢控制不佳的糖尿病患者血清T3水平比正常受试者低13.0%（P<0.05）。各组间血清rT3、T4和TSH未观察到差异。这些发现表明，在糖尿病患者中，代谢紊乱比血清rT三碘甲状腺原氨酸更容易引起血清T3的改变。然而，血清T3的改变并不是糖尿病患者中度代谢紊乱的敏感指标。
