Becker D J, Brown D R, Steranka B H, Drash A L
Am J Dis Child. 1983 Mar;137(3):241-6. doi: 10.1001/archpedi.1983.02140290033009.
Thirty-five patients with diabetic ketosis were given initial intravenous (IV) potassium replacement as phosphate (N = 13) or chloride (N = 13), or received no potassium replacement other than that contained in a normal diet (N = 9). All patients experienced a slight decrease in serum calcium level by 12 hours after the start of insulin therapy, but there was no statistically significant change in serum ionized calcium values. The phosphorus-supplemented group had significantly lower serum phosphorus concentrations at 24 and 36 hours when compared with patients receiving no IV hydration and excreted significantly more phosphorus during the first 12 hours of the study than either of the other two groups of patients. Our use of phosphorus supplements (4.7 to 28.5 mg/kg) did not cause abnormalities in calcium metabolism but did not prevent late hypophosphatemia.
35例糖尿病酮症患者开始接受静脉补钾，其中13例补磷，13例补氯，9例除正常饮食中所含钾外未接受其他补钾治疗。所有患者在胰岛素治疗开始后12小时血清钙水平均略有下降，但血清离子钙值无统计学显著变化。与未接受静脉补液的患者相比，补磷组在24小时和36小时时血清磷浓度显著降低，且在研究的前12小时内排出的磷显著多于其他两组患者。我们使用的磷补充剂（4.7至28.5mg/kg）未引起钙代谢异常，但未能预防晚期低磷血症。
