Bobzien B, Yasunami Y, Majercik M, Lacy P E, Davie J M
Diabetes. 1983 Mar;32(3):213-6. doi: 10.2337/diab.32.3.213.
Freshly isolated rat islets were transplanted into the testis of diabetic mice. The intratesticular islet xenografts produced normoglycemia in the diabetic recipients. The survival time of the intratesticular xenografts was significantly longer than intrasplenic, intrahepatic, and renal subcapsular sites of transplantation of xenografts of freshly isolated rat islets. Three of the recipients with intratesticular islet grafts were still normoglycemic at 60 days after transplantation, and orchidectomy resulted in a return to the diabetic state. The findings indicate that the testis provided a more privileged immunologic site than either the spleen, liver, or kidney and the lower temperature of the testis apparently did not affect the function of the islet grafts since the recipients became normoglycemic.
将新鲜分离的大鼠胰岛移植到糖尿病小鼠的睾丸中。睾丸内胰岛异种移植使糖尿病受体恢复正常血糖水平。睾丸内异种移植的存活时间明显长于新鲜分离的大鼠胰岛异种移植的脾内、肝内和肾被膜下移植部位。三只接受睾丸内胰岛移植的受体在移植后60天仍保持正常血糖水平，而睾丸切除导致其恢复到糖尿病状态。这些发现表明，睾丸提供了一个比脾脏、肝脏或肾脏更具免疫特权的部位，而且睾丸较低的温度显然并未影响胰岛移植的功能，因为受体的血糖恢复了正常。
