Levine L S, Wright P G, Marcus F
Acta Endocrinol (Copenh). 1983 Feb;102(2):240-5. doi: 10.1530/acta.0.1020240.
Rats fed a 6% protein diet for 14 weeks showed a normal glucose tolerance but failed to release immunoreactive insulin (IRI), following iv glucose. Furthermore the isolated perfused pancreas of the rats fed the 6% protein diet secreted eleven times less IRI than the isolated pancreas prepared from the rats reared on an 18% protein diet when both were subjected to the same glucose challenge. This difference occurred despite the fact that the total IRI content of the pancreas' was not significantly different between the two groups. In the protein-malnourished rats it is suggested that the normal glucose tolerance response, despite the failure to release a concommitant amount of IRI, may indicate increased sensitivity to IRI or may be due to the secretion in these animals of a biologically active insulin, which shows no immunological cross-reactivity with pancreatic insulin. Alternately there may be increased peripheral glucose utilisation in the low protein rats.
喂食6%蛋白质饮食14周的大鼠表现出正常的葡萄糖耐量，但静脉注射葡萄糖后未能释放免疫反应性胰岛素（IRI）。此外，当对喂食6%蛋白质饮食的大鼠和以18%蛋白质饮食饲养的大鼠的离体灌注胰腺进行相同的葡萄糖刺激时，前者分泌的IRI比后者少11倍。尽管两组胰腺的总IRI含量没有显著差异，但仍出现了这种差异。在蛋白质营养不良的大鼠中，尽管未能释放相应量的IRI，但正常的葡萄糖耐量反应可能表明对IRI的敏感性增加，或者可能是由于这些动物分泌了一种生物活性胰岛素，该胰岛素与胰腺胰岛素没有免疫交叉反应。或者，低蛋白大鼠的外周葡萄糖利用率可能会增加。
