[Effect of the aeration and agitation parameters on the oxytetracycline biosynthesis process under microkinetic conditions].

The effect of the aeration levels in flasks on the rate of oxytetracycline biosynthesis and other kinetic characteristics was studied. It was shown that changes in the medium volume in flasks, dilution of the fermentation broth with water or its filtrate and the use of oxygen for aeration had a significant effect on the characteristics studied. Special experiments with low concentrations of the biomass were performed for investigation of the effect of dissolved carbon dioxide on the kinetics of the process.