Maksimova E A, Semenova L E, Bylinkina E S
Antibiotiki. 1982 Oct;27(10):753-7.
An increase in the power input for agitation from 0.4 to 2.7 kw/m3 in oxytetracycline biosynthesis stimulated the antibiotic production due to an accelerated use of carbohydrate and nitrogen and an earlier transition of the culture to the phase of the antibiotic biosynthesis. The procedure for determination of the aeration and agitation conditions by the maximum rate of the oxygen uptake is described. The procedure is recommended for the use in the studies on determination of such conditions for the biosynthesis of of oxytetracycline in large apparatus.
土霉素生物合成中搅拌的功率输入从0.4千瓦/立方米增加到2.7千瓦/立方米，刺激了抗生素的产生，这是由于碳水化合物和氮的利用加速以及培养物更早地过渡到抗生素生物合成阶段。描述了通过最大摄氧率来确定通气和搅拌条件的方法。推荐该方法用于在大型装置中测定土霉素生物合成此类条件的研究。
