类风湿关节炎中的金诱导肾病与HLA II类基因
Gold induced nephropathy in rheumatoid arthritis and HLA class II genes.
作者信息
Sakkas L I, Chikanza I C, Vaughan R W, Welsh K I, Panayi G S
机构信息
Molecular Immunogenetics Units, United Medical School, Guy's Hospital, London, United Kingdom.
出版信息
Ann Rheum Dis. 1993 Apr;52(4):300-1. doi: 10.1136/ard.52.4.300.
OBJECTIVES
To elucidate the role of HLA-DRB, -DQA, and -DQB genes in patients with rheumatoid arthritis (RA) who developed gold induced nephropathy.
METHODS
Southern blot analysis of HLA-DRB, -DQA, and -DQB genes was performed on DNA from 27 patients with RA with gold induced nephropathy, 37 patients with RA who were treated with gold but did not develop nephropathy, and 122 ethnically matched normal subjects.
RESULTS
The 4.7 kb DQA1/Taq I band associated with DQA1*0501 and DR3 and DR5 was found in 16 (59%) patients with gold induced nephropathy compared with five (14%) patients without gold induced nephropathy.
CONCLUSION
It is concluded that HLA-DQA region genes may be an important susceptibility factor for the development of gold induced nephropathy in patients with RA.
目的
阐明人类白细胞抗原-DRB、-DQA和-DQB基因在发生金诱导肾病的类风湿关节炎（RA）患者中的作用。
方法
对27例发生金诱导肾病的RA患者、37例接受金治疗但未发生肾病的RA患者以及122名种族匹配的正常受试者的DNA进行HLA-DRB、-DQA和-DQB基因的Southern印迹分析。
结果
与DQA1*0501以及DR3和DR5相关的4.7 kb DQA1/Taq I条带，在16例（59%）发生金诱导肾病的患者中出现，而在未发生金诱导肾病的5例（14%）患者中出现。
结论
得出结论，HLA-DQA区域基因可能是RA患者发生金诱导肾病的一个重要易感因素。
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