一种极具成本效益的地中海贫血大规模筛查方法。
A highly cost effective method of mass screening for thalassaemia.
作者信息
Silvestroni E, Bianco I
出版信息
Br Med J (Clin Res Ed). 1983 Mar 26;286(6370):1007-9. doi: 10.1136/bmj.286.6370.1007.
A simple, fast, and reliable two step procedure for the detection of non-alpha-thalassaemias in mass screening programmes is presented. Step 1 consists of a study of red cell morphology and a one tube red cell osmotic fragility tests. This step eliminates the non-thalassaemic samples; the rest are processed through step 2, consisting of determination of red cell indices and haemoglobin studies. Over the past seven years this procedure has been used at this centre in mass screening secondary school students in Latium. Blood samples from 289 763 students were examined, and 6838 cases of thalassaemia detected. It is estimated that 0.35 +/- 0.25% of subjects with thalassaemia escaped detection by this procedure.
本文介绍了一种用于大规模筛查项目中检测非α地中海贫血的简单、快速且可靠的两步法。第一步包括红细胞形态学研究和单管红细胞渗透脆性试验。这一步可排除非地中海贫血样本；其余样本进入第二步，包括测定红细胞指数和血红蛋白研究。在过去七年里，该方法已在本中心用于对拉齐奥地区中学生的大规模筛查。共检测了289763名学生的血样，发现6838例地中海贫血病例。据估计，该方法漏检了0.35±0.25%的地中海贫血患者。
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