Grilli S, De Giovanni C, Prodi G, Giumanini A G
Gan. 1978 Feb;69(1):39-45.
7-Methylguanine is the main compound resulting from in vivo interaction between dimethylnitrosamine (DMNA) and nucleic acids, detected after strong acid hydrolysis. However, enzymic and alkaline hydrolysis of nucleic acids leads to quantitative liberation of methylamine. Methylamine isolated from liver nucleic acids of 15N-DMNA-treated rats has molecular weight of 31, thus demonstrating that DMNA-nitrogen is not involved in the binding.
7-甲基鸟嘌呤是二甲基亚硝胺（DMNA）与核酸在体内相互作用产生的主要化合物，在强酸水解后可检测到。然而，核酸的酶解和碱解会导致甲胺定量释放。从经15N-DMNA处理的大鼠肝脏核酸中分离出的甲胺分子量为31，因此表明DMNA中的氮不参与结合。
