Grilli S, Prodi G
Gan. 1975 Oct;66(5):473-80.
The incubation of dimethylnitrosoamine (DMNA) in the presence of rat liver microsomes leads to production of formaldehyde, formic acid, methylamine, and N-methylhydrazine. When pH 5-enzymes are added to the medium there is also the formation of N-methylhydroxylamide and N,N-dimethylhydrazine. The last compound is the only metabolite produced, to a lesser extent, by the pH 5-enzymes. Thus, the denitrosated or non-denitrosated metabolites are produced either by an oxidative dealkylation and by a reduction of DMNA, catalysed by microsomal and cellular soluble enzymes.
在大鼠肝微粒体存在的情况下，二甲基亚硝胺（DMNA）的温育会导致甲醛、甲酸、甲胺和N - 甲基肼的产生。当向培养基中添加pH 5 - 酶时，还会形成N - 甲基羟胺和N，N - 二甲基肼。最后一种化合物是pH 5 - 酶产生的唯一代谢产物，产量较少。因此，脱亚硝基或未脱亚硝基的代谢产物是由微粒体和细胞可溶性酶催化的氧化脱烷基作用以及DMNA的还原作用产生的。
