重组猪γ干扰素的抗病毒和抗原特性
Antiviral and antigenic properties of recombinant porcine interferon gamma.
作者信息
Charley B, McCullough K, Martinod S
机构信息
INRA, Station de Recherches de Virologie et d'Immunologie, Jouy-en-Josas, France.
出版信息
Vet Immunol Immunopathol. 1988 Sep;19(2):95-103. doi: 10.1016/0165-2427(88)90001-3.
Abstract
Recombinant porcine interferon gamma (rPoIFN gamma) induced a dose-dependent inhibition of the cytopathic effect produced by vesicular stomatitis virus (VSV) challenge of both homologous and heterologous (bovine) cell lines. In addition, an antiviral effect of rPoIFN gamma was demonstrable against the coronavirus transmissible gastroenteritis virus (TGEV) infection of porcine epithelial cells and of pulmonary macrophages. A rabbit anti-PoIFN gamma antiserum was prepared and shown to specifically neutralize the antiviral effects of natural and recombinant porcine IFN gamma preparations. This antiserum could also neutralize recombinant bovine IFN gamma but not recombinant human IFN gamma. These results suggest antigenic homology of porcine and bovine IFN gamma but antigenic differences between these molecules and human IFN gamma.
摘要
重组猪干扰素γ（rPoIFNγ）对水泡性口炎病毒（VSV）攻击同源和异源（牛）细胞系所产生的细胞病变效应具有剂量依赖性抑制作用。此外，rPoIFNγ对猪上皮细胞和肺巨噬细胞的冠状病毒传染性胃肠炎病毒（TGEV）感染具有抗病毒作用。制备了兔抗PoIFNγ抗血清，并证明其能特异性中和天然和重组猪干扰素γ制剂的抗病毒作用。该抗血清也能中和重组牛干扰素γ，但不能中和重组人干扰素γ。这些结果表明猪和牛干扰素γ具有抗原同源性，但这些分子与人干扰素γ之间存在抗原差异。
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