Cauda R, Tyring S K, Grossi C E, Tilden A B, Hatch K D, Sams W M, Baron S, Whitley R J
J Clin Immunol. 1987 Jul;7(4):304-11. doi: 10.1007/BF00915552.
Peripheral blood mononuclear cells were obtained from 20 untreated condyloma acuminatum patients and from an equal number of sex- and age-matched controls and assayed for cell surface antigen expression, natural killer activity, and lymphokine production. Patient peripheral blood mononuclear cells had significantly lower helper-to-suppressor T-cell ratios (Leu3/Leu2) (P less than 0.05) and significantly higher percentages of Leu 2+ Tac+ cells (activated suppressor/cytotoxic cells) (P less than 0.05) and Leu 2+ OKM1+ cells (suppressor cells) (P less than 0.01). Natural killer activity of condyloma acuminatum patients was significantly lower (P less than 0.05) than that of controls. Production of interleukin-2 and interferon gamma, but not interferon alpha, was significantly (P less than 0.01) decreased in condyloma acuminatum patients. There was an inverse correlation between the in vitro production of interleukin-2 and interferon gamma and the percentage of Leu 2+ OKM1+ cells (suppressor) (P less than 0.01). Thus, patients with condyloma acuminatum differ from controls by demonstrating decreased natural killer-cell activity, decreased production of lymphokines which enhance natural killer-cell activity (i.e., interferon gamma and interleukin-2), and an increased proportion of T cells with a suppressor phenotype.
从20例未经治疗的尖锐湿疣患者以及数量相同、性别和年龄匹配的对照者中获取外周血单个核细胞，并检测其细胞表面抗原表达、自然杀伤活性及淋巴因子产生情况。患者外周血单个核细胞的辅助性T细胞与抑制性T细胞比值（Leu3/Leu2）显著降低（P<0.05），Leu 2+ Tac+细胞（活化的抑制性/细胞毒性细胞）和Leu 2+ OKM1+细胞（抑制性细胞）的百分比显著升高（P<0.05和P<0.01）。尖锐湿疣患者的自然杀伤活性显著低于对照组（P<0.05）。尖锐湿疣患者白细胞介素-2和干扰素γ的产生显著减少（P<0.01），但干扰素α的产生无明显变化。白细胞介素-2和干扰素γ的体外产生与Leu 2+ OKM1+细胞（抑制性细胞）的百分比呈负相关（P<0.01）。因此，尖锐湿疣患者与对照组的不同之处在于自然杀伤细胞活性降低、增强自然杀伤细胞活性的淋巴因子（即干扰素γ和白细胞介素-2）产生减少，以及具有抑制性表型的T细胞比例增加。
