Klein J R, Bevan M J
J Immunol. 1983 Apr;130(4):1780-3.
We have examined the relationship between the Con A-mediated induction of CTL effector function and immune IFN secretion in congenitally athymic nude mice. Spleen cells from young adult nude mice (2 mo of age) were found to require an exogenous source of IL 2 for the activation of a CTL effector response and for the release of immune IFN. However, the response of spleen cells from nude mice 9 mo of age differed from that of younger animals in that exogenous IL 2 was not required for the activation of CTL effector function and immune IFN secretion. Spleen cells from old nude mice were found to be capable of making IL 2 upon Con A stimulation similar to normal thymus-bearing animals. The data demonstrate that the maturation of IL 2-secreting cells can occur in athymic mice, that IL 2 is a requisite signal not only for the development of CTL effector function but also for the production of immune IFN, and that CTL effector function and immune IFN release are closely associated immunologic events.
我们研究了在先天性无胸腺裸鼠中伴刀豆球蛋白A介导的细胞毒性T淋巴细胞（CTL）效应功能诱导与免疫干扰素分泌之间的关系。发现来自年轻成年裸鼠（2月龄）的脾细胞需要外源性白细胞介素2（IL 2）来激活CTL效应反应并释放免疫干扰素。然而，9月龄裸鼠的脾细胞反应与年轻动物不同，因为激活CTL效应功能和免疫干扰素分泌不需要外源性IL 2。发现来自老年裸鼠的脾细胞在伴刀豆球蛋白A刺激下能够产生IL 2，类似于正常有胸腺的动物。数据表明，分泌IL 2的细胞可在无胸腺小鼠中成熟，IL 2不仅是CTL效应功能发展的必要信号，也是免疫干扰素产生的必要信号，并且CTL效应功能和免疫干扰素释放是密切相关的免疫事件。
