Hodges J K, Eastman S A, Jenkins N
J Endocrinol. 1983 Mar;96(3):443-50. doi: 10.1677/joe.0.0960443.
A sex hormone binding globulin (SHBG) similar to human SHBG was identified in marmoset serum based on its gel electrophoretic mobility, isoelectric point and steroid binding properties. Levels of serum SHBG were measured in immature and mature males, immature females and females during the luteal phase and pregnancy; serum progesterone, 5 alpha-dihydrotestosterone (5 alpha-DHT), testosterone, oestradiol-17 beta and oestrone were also measured. Mean (+/- S.E.M.) concentrations of SHBG in immature males (336 +/- 19 nmol/l) were higher (P less than 0.01) than those in mature males (251 +/- 13 nmol/l), whereas values in the groups of females were similar (359 +/- 12, 395 +/- 17, 397 +/- 39 nmol/l in immature, non-pregnant and pregnant females respectively). There was an inverse relationship between SHBG and the levels of testosterone (r = -0.67) and 5 alpha-DHT (r = -0.86) in males, but the correlation was significant (P less than 0.05) only for 5 alpha-DHT. There was no correlation between levels of SHBG and oestrogens in males or between levels of SHBG and any of the steroids measured in females. Equilibrium dialysis was used to assess the percentage of steroid in serum in the unbound form. Mean percentage values for unbound testosterone and 5 alpha-DHT were lower in immature males than in mature males (P less than 0.01) and negatively correlated with levels of SHBG (r = -0.78, testosterone; r = -0.56, 5 alpha-DHT).
基于其凝胶电泳迁移率、等电点和类固醇结合特性，在狨猴血清中鉴定出一种与人性激素结合球蛋白（SHBG）相似的物质。对未成熟和成熟雄性、未成熟雌性以及处于黄体期和孕期的雌性的血清SHBG水平进行了测量；同时还测量了血清孕酮、5α-双氢睾酮（5α-DHT）、睾酮、雌二醇-17β和雌酮。未成熟雄性的SHBG平均（±标准误）浓度（336±19 nmol/L）高于成熟雄性（251±13 nmol/L）（P<0.01），而雌性组的值相似（未成熟、未怀孕和怀孕雌性分别为359±12、395±17、397±39 nmol/L）。雄性中SHBG与睾酮水平（r = -0.67）和5α-DHT水平（r = -0.86）呈负相关，但仅5α-DHT的相关性显著（P<0.05）。雄性中SHBG水平与雌激素之间或雌性中SHBG水平与所测任何类固醇之间均无相关性。采用平衡透析法评估血清中未结合形式类固醇的百分比。未成熟雄性中未结合睾酮和5α-DHT的平均百分比值低于成熟雄性（P<0.01），且与SHBG水平呈负相关（r = -0.78，睾酮；r = -0.56，5α-DHT）。
