Theobald P, Pfau P
Geburtshilfe Frauenheilkd. 1978 Mar;38(3):212-9.
Report on three cases of choriocarcinoma which showed interesting features. In the first case a living male infant was delivered two years following chemotherapy for choriocarcinoma and the infant showed no chromosomal abnormalities. In the second case a choriocarcinoma developed three years following a post-partum tubal ligation and the localized tumor was successfully treated by hysterectomy without chemotherapy. In the third case the uterine tumour was refractory to chemotherapy with Actinomycin D and methotrexate and required a hysterectomy. The value of HCG and HPL titres in the differential diagnosis and the value of the microscopic results of the currettings are discussed. The possibility of chromosomal damage to infants born following chemotherapy of the mother is mentioned.
三例绒毛膜癌病例报告，这些病例呈现出有趣的特征。第一例中，一名存活男婴在绒毛膜癌化疗两年后出生，该婴儿未显示染色体异常。第二例中，绒毛膜癌在产后输卵管结扎三年后发生，局部肿瘤通过子宫切除术成功治疗，未进行化疗。第三例中，子宫肿瘤对放线菌素D和甲氨蝶呤化疗耐药，需要进行子宫切除术。讨论了人绒毛膜促性腺激素（HCG）和人胎盘催乳素（HPL）滴度在鉴别诊断中的价值以及刮宫组织显微镜检查结果的价值。还提到了母亲化疗后出生的婴儿发生染色体损伤的可能性。
