Philipsen H P, Fisker A V
J Oral Pathol. 1983 Feb;12(1):30-6. doi: 10.1111/j.1600-0714.1983.tb00313.x.
Thrice weekly applications of carcinogen 4-nitroquinoline N-oxide to rat oral mucosa, induced focal acantholytic dyskeratosis (FAD) in about 50% of the animals. Mucosa overlying bone (palate and attached buccal gingiva) was the area of predilection. The number of oral foci per affected animal ranged between 1 and 3. Histologically, the experimental FAD foci showed all the characteristic features described for human focal acantholytic dyskeratosis. FAD appeared unrelated to malignancy development. It is suggested that FAD represents an induced epithelial differentiation or maturation defect caused by a variety of stimuli among which are chemical carcinogens. The present experimental model seems suitable for further histo- and cytopathogenetic studies.
每周三次将致癌物4-硝基喹啉N-氧化物应用于大鼠口腔黏膜，约50%的动物诱发了局灶性棘层松解性角化不良（FAD）。覆盖骨骼的黏膜（硬腭和附着的颊侧牙龈）是好发部位。每只受影响动物的口腔病灶数量在1至3个之间。组织学上，实验性FAD病灶表现出所有已描述的人类局灶性棘层松解性角化不良的特征。FAD似乎与恶性肿瘤的发生无关。有人提出，FAD代表由多种刺激因素引起的上皮分化或成熟缺陷，其中包括化学致癌物。目前的实验模型似乎适合进一步的组织学和细胞发病机制研究。
