Navarro C M, Paes de Almeida O, Scully C
Department of Oral Pathology, Faculty of Odontology of Piracicaba-UNICAMP, Piracicaba, SP, Brazil.
Bull Tokyo Dent Coll. 1993 Nov;34(4):191-4.
This study examines the effects of xerostomia on the development of mucosal changes proceeding carcinoma in rats painted orally with 4-nitroquinoline N-oxide (4NQO). Sialoadenectomy enhanced the incidence of focal acantholytic dyskeratosis (FAD) on the palate and tongue of rats painted on the palate with 0.5% 4NQO three times weekly. At one month, no changes were observed. After two months of painting with 4NQO, sialoadenectomized rats, but not controls, had FAD. After three months, FAD was seen in both test and control groups, but the incidence of FAD was higher in the test group and seen more on the palate than on the tongue of xerostomic animals. Neither test nor control animals developed carcinoma within this study period.
本研究考察了口干症对经口涂抹4-硝基喹啉-N-氧化物（4NQO）的大鼠黏膜变化发展至癌的影响。唾液腺切除术增加了每周三次在腭部涂抹0.5% 4NQO的大鼠腭部和舌部局灶性棘层松解性角化不良（FAD）的发生率。在一个月时，未观察到变化。在用4NQO涂抹两个月后，唾液腺切除的大鼠出现了FAD，而对照组未出现。三个月后，试验组和对照组均出现了FAD，但试验组FAD的发生率更高，且在口干动物的腭部比舌部更常见。在本研究期间，试验组和对照组动物均未发生癌变。
