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围产期营养不良对大鼠成年期生理和行为反应性的影响。

Influence of perinatal malnutrition on adult physiological and behavioral reactivity in rats.

作者信息

Wiener S G, Robinson L, Levine S

出版信息

Physiol Behav. 1983 Jan;30(1):41-50. doi: 10.1016/0031-9384(83)90036-7.

DOI:10.1016/0031-9384(83)90036-7
PMID:6403954
Abstract

A series of experiments examined the behavioral and pituitary-adrenal response to novelty of perinatally malnourished rats tested as adults after nutritional rehabilitation begun at weaning. Neither the behavioral measures of ambulation, rearing and defecation, nor the plasma corticosterone response to a brief exposure to an open field differentiated the previously malnourished subjects from controls. Similar to controls, previously malnourished subjects were also capable of displaying a graded corticoid elevation to environments increasingly different from the home cage. However, exploratory behavior, as measured by head-dip frequency and duration in the hole-board, was reduced in the previously malnourished rats. Although latency and amount of fluid consumed in a novel environment did not differ, previously malnourished rats were unable to use the cues associated with a consummatory behavior to modulate the pituitary-adrenal response to novelty. Thus, perinatal malnutrition does not influence either the behavioral or physiological activational response to novel stimulation but appears to alter the ability of the animal to use a consummatory behavior to modulate this response.

摘要

一系列实验研究了断奶后开始营养恢复的围产期营养不良大鼠成年后对新异刺激的行为反应和垂体 - 肾上腺反应。无论是行走、竖毛和排便的行为指标,还是短暂暴露于旷场后的血浆皮质酮反应,都无法区分先前营养不良的大鼠和对照组。与对照组相似,先前营养不良的大鼠也能够对与家笼环境差异越来越大的环境表现出分级的皮质激素升高。然而,通过洞板实验中探头频率和持续时间测量的探索行为在先前营养不良的大鼠中有所减少。尽管在新环境中饮水的潜伏期和饮水量没有差异,但先前营养不良的大鼠无法利用与 consummatory 行为相关的线索来调节垂体 - 肾上腺对新异刺激的反应。因此,围产期营养不良既不影响对新异刺激的行为或生理激活反应,但似乎会改变动物利用 consummatory 行为来调节这种反应的能力。 (注:consummatory 行为此处根据语境推测是指完成某种行为如获取食物等,因原文未明确解释,可能翻译不太准确。)

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