Herbert D C, Carrillo A J
Horm Metab Res. 1982 Apr;14(4):205-7. doi: 10.1055/s-2007-1018969.
Male rats were fed an 8% low protein diet for 30 consecutive days beginning at 20 days of age. On day 50, the effect of the diet was evaluated on the hypophyseal-adrenal axis and the observations compared with those noted in age-matched controls fed a standard laboratory diet. The malnourished animals had significantly larger adrenal gland weights, relative to body size, and higher levels of serum corticosterone. Additionally, the number of ACTH-secreting cells in the pituitary glands of these rats was 63.8% greater than that present in the controls. These results suggest that ACTH secretion and adrenocortical physiology are stimulated under conditions of experimentally induced protein-calorie malnutrition.
雄性大鼠从20日龄开始连续30天喂食8%的低蛋白饮食。在第50天，评估该饮食对垂体-肾上腺轴的影响，并将观察结果与喂食标准实验室饮食的年龄匹配对照组的观察结果进行比较。相对于体型，营养不良的动物肾上腺重量明显更大，血清皮质酮水平更高。此外，这些大鼠垂体中促肾上腺皮质激素分泌细胞的数量比对照组多63.8%。这些结果表明，在实验诱导的蛋白质-热量营养不良的情况下，促肾上腺皮质激素分泌和肾上腺皮质生理受到刺激。
