[Effect of different doses of dichlorodiphenyl on the cytochrome P-450 level and lipid peroxidation rate in the rat liver].

A single administration of increasing doses of dichlorodiphenyl (60-2400 mg/kg) leads to an increase in the content of cytochrome P-450 in rat liver. Initially, the increase rate is high whereupon, within the dose ranges of 800-1600 mg/kg, it does not virtually change, constituting 270-290%. A higher dose, 2400 mg/kg, produces an increase in the hemoprotein level only in individual animals. When given in cytochrome P-450-induction doses, dichlorodiphenyl has a stimulant action on the non-enzymatic system of lipid peroxidation in rat liver.