Inhibition of histidine decarboxylase and tumour promoter-induced arachidonic acid release by lecanoric acid analogues.
作者信息
Umezawa K, Muramatsu S, Ishizuka M, Sawa T, Takeuchi T, Matsushima T
出版信息
Biochem Biophys Res Commun. 1983 Feb 10;110(3):733-9. doi: 10.1016/0006-291x(83)91022-7.
PMID:6404261
Abstract
Lecanoric acid analogues containing benzanilide structure inhibited histidine decarboxylase and arachidonic acid release from the cell membrane phospholipids induced by a tumour promoter, 12-O-tetradecanoylphorbol-13-acetate. But they did not inhibit cellular binding of phorbol-12,13-dibutylate. Lecanoric acid analogues also inhibited prostaglandin synthetase and delayed-type hypersensitivity responses against sheep red blood cells in mice. Thus, lecanoric acid analogues antagonized several enzymic and cellular effects of the tumour promoter.
摘要
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引用本文的文献
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Inhibition of tumor promotion by a lecanoric acid analogue.
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J Cancer Res Clin Oncol. 1986;111(3):177-81. doi: 10.1007/BF00389230.
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