Torre V, Owen W G
Biophys J. 1983 Mar;41(3):305-24. doi: 10.1016/S0006-3495(83)84443-9.
The electrical spread of excitation in the network of rod photoreceptors was studied by intracellular recording in the isolated, perfused retina of the toad, Bufo marinus. Experiments with dim, bar-shaped flashes of light revealed that the rod network behaves as a high-pass filter to laterally propagating small signals. Such a behavior had been found earlier in the turtle (Detwiler et al., 1980). Three electrical equivalent circuit models that can explain this behavior were considered and analytical solutions to the network equations were obtained. By fitting these analytical expressions to linear responses elicited by weak light flashes and to voltage excursions elicited by extrinsic current injections, values for the circuit parameters were determined. Values obtained by independent methods were consistent. The effects of changing each of these parameters in turn upon the high-pass filtering of small signals were then predicted. These predictions provided a framework for an analysis of the ionic basis of the underlying mechanism, which is described in the following paper.
通过在海蟾蜍（Bufo marinus）离体灌注视网膜上进行细胞内记录，研究了视杆光感受器网络中兴奋的电传播。使用昏暗的条形闪光进行的实验表明，视杆网络对横向传播的小信号表现为高通滤波器。这种行为早在乌龟中就已被发现（Detwiler等人，1980年）。考虑了三种能够解释这种行为的等效电路模型，并获得了网络方程的解析解。通过将这些解析表达式拟合到弱闪光引起的线性响应以及外部电流注入引起的电压偏移，确定了电路参数的值。通过独立方法获得的值是一致的。然后预测了依次改变这些参数中的每一个对小信号高通滤波的影响。这些预测为分析潜在机制的离子基础提供了一个框架，这将在后续论文中进行描述。
