[降钙素在妊娠大鼠中的作用：体内/体外与1,25-二羟胆钙化醇对胎儿骨吸收的相互作用]
[Role of calcitonin in pregnant rats : interaction with 1,25-dihydroxycholecalciferol on fetal bone resorption in vivo/in vitro].
作者信息
Rebut-Bonneton C, Martin J L, Miravet L, Amor B
出版信息
C R Seances Acad Sci III. 1983 Jan 10;296(1):63-6.
PMID:6404511
Abstract
We studied in pregnant Rat the effect of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) alone or associated with calcitonin on fetal bone resorption measured by organ culture. 1,25(OH)2D3 (0.1 microgram per day) reduced fetal weight and increased fetal bone resorption. Calcitonin (30 mU/hr.) alone had no significant effects but, associated with 1,25(OH)2D3, it protected mother and foetus against the effect of the vitamin D3 metabolite.
摘要
我们在怀孕大鼠中研究了单独使用1,25 - 二羟基胆钙化醇（1,25(OH)₂D₃）或与降钙素联合使用对通过器官培养测量的胎儿骨吸收的影响。1,25(OH)₂D₃（每天0.1微克）降低了胎儿体重并增加了胎儿骨吸收。单独使用降钙素（30 mU/小时）没有显著影响，但与1,25(OH)₂D₃联合使用时，它保护母体和胎儿免受维生素D₃代谢产物的影响。
Zotero 插件