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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Martínez P, Palau J

Comp Biochem Physiol B. 1983;74(3):611-7. doi: 10.1016/0305-0491(83)90237-7.

Very-lysine-rich histone of a mammal (calf thymus), two sea urchins (Arbacia lixula and Paracentrotus lividus) and a sea cucumber (Holothuria tubulosa) were compared by using immunological techniques. 2. The degree of antigenic variability among all these histones was measured by quantitative microcomplement fixation. An evoluntionary diagram for this group of histones has been established. 3. The histone from sea cucumber is placed in an intermediate situation between those for calf thymus and sea urchins, and the immunological distance between the histones of the two urchins is very short.

运用免疫学技术对一种哺乳动物（小牛胸腺）、两种海胆（紫球海胆和地中海海胆）以及一种海参（管海参）的富含赖氨酸的组蛋白进行了比较。2. 通过定量微量补体结合法测定了所有这些组蛋白之间的抗原变异程度。已建立了这一组组蛋白的进化图谱。3. 海参的组蛋白处于小牛胸腺和海胆组蛋白之间的中间位置，并且两种海胆组蛋白之间的免疫距离非常短。

Martínez P, Palau J

Comp Biochem Physiol B. 1983;74(3):611-7. doi: 10.1016/0305-0491(83)90237-7.

Very-lysine-rich histone of a mammal (calf thymus), two sea urchins (Arbacia lixula and Paracentrotus lividus) and a sea cucumber (Holothuria tubulosa) were compared by using immunological techniques. 2. The degree of antigenic variability among all these histones was measured by quantitative microcomplement fixation. An evoluntionary diagram for this group of histones has been established. 3. The histone from sea cucumber is placed in an intermediate situation between those for calf thymus and sea urchins, and the immunological distance between the histones of the two urchins is very short.

运用免疫学技术对一种哺乳动物（小牛胸腺）、两种海胆（紫球海胆和地中海海胆）以及一种海参（管海参）的富含赖氨酸的组蛋白进行了比较。2. 通过定量微量补体结合法测定了所有这些组蛋白之间的抗原变异程度。已建立了这一组组蛋白的进化图谱。3. 海参的组蛋白处于小牛胸腺和海胆组蛋白之间的中间位置，并且两种海胆组蛋白之间的免疫距离非常短。