Díaz S, Peralta O, Juez G, Herreros C, Casado M E, Salvatierra A M, Miranda P, Durán E, Croxatto H B
Contraception. 1983 Jan;27(1):1-11. doi: 10.1016/0010-7824(83)90051-3.
The study was designed to test the short-term influence of a low-dose combined oral contraceptive upon lactation and infant growth when treatment was initiated at day 30 postpartum. The contraceptive tested contained ethinyl estradiol 0.03 mg and levonorgestrel 0.15 mg. Two control groups were formed by women who received either an oral placebo or an injectable placebo at day 30 postpartum. An exacting list of requirements for admission and continuation in the study was applied to all groups. The oral contraceptive group had a lower percentage of cases in exclusive breastfeeding at day 91 postpartum when compared to both control groups. Infants in the oral contraceptive group showed a significantly lower average absolute weight at days 61 and 91 postpartum and a significantly lower average daily weight increase during the first month of treatment when compared to both control groups. It was concluded that the oral contraceptive tested had a negative influence upon lactation and child growth.
本研究旨在测试产后30天开始使用低剂量复方口服避孕药对泌乳和婴儿生长的短期影响。所测试的避孕药含有0.03毫克炔雌醇和0.15毫克左炔诺孕酮。两个对照组由产后30天接受口服安慰剂或注射用安慰剂的女性组成。对所有组均采用了严格的研究准入和持续要求清单。与两个对照组相比，口服避孕药组在产后91天纯母乳喂养的病例百分比更低。与两个对照组相比，口服避孕药组的婴儿在产后61天和91天的平均绝对体重显著更低，且在治疗的第一个月平均每日体重增加显著更低。得出的结论是，所测试的口服避孕药对泌乳和儿童生长有负面影响。
