Croxatto H B, Díaz S, Peralta O, Juez G, Herreros C, Casado M E, Salvatierra A M, Miranda P, Durán E
Contraception. 1983 Jan;27(1):13-25. doi: 10.1016/0010-7824(83)90052-5.
The study was designed to test the long-term influence of a low-dose combined oral contraceptive upon lactation and infant growth when treatment was initiated at day 30 postpartum. The contraceptive tested contained ethinyl estradiol 0.03 mg and levonorgestrel 0.15 mg. Two control groups were formed by women who received an injectable placebo or a Copper T at day 30 postpartum. Women in the injectable placebo group received non-hormonal contraceptives at day 90 postpartum. An exacting list of requirements for admission and continuation in the study was applied to all groups. The oral contraceptive group had a significantly lower percentage of cases in full nursing from the 4th through the 10th postpartum month when compared to both control groups. The average absolute weight of infants in the oral contraceptive group was significantly lower at several ages when compared to the placebo group but not when compared to the Copper T group. No adverse side effects upon infant's health were detected. It was concluded that the oral contraceptive tested showed a moderate inhibitory influence upon lactation when treatment was initiated at the beginning of the second postpartum month.
本研究旨在测试产后30天开始使用低剂量复方口服避孕药对哺乳及婴儿生长的长期影响。所测试的避孕药含0.03毫克炔雌醇和0.15毫克左炔诺孕酮。两个对照组由产后30天接受注射用安慰剂或铜T的女性组成。注射用安慰剂组的女性在产后90天接受非激素避孕药。对所有组都采用了严格的纳入和继续参与研究的要求清单。与两个对照组相比，口服避孕药组在产后第4个月至第10个月进行纯母乳喂养的病例百分比显著更低。与安慰剂组相比，口服避孕药组婴儿在几个年龄段的平均绝对体重显著更低，但与铜T组相比则不然。未检测到对婴儿健康的不良副作用。得出的结论是，在产后第二个月开始治疗时，所测试的口服避孕药对哺乳有中度抑制作用。
