Mosca W, Plaja J
J Clin Microbiol. 1981 Jul;14(1):1-5. doi: 10.1128/jcm.14.1.1-5.1981.
Reactivity to Trypanosoma cruzi antigens and autoreactivity to heart antigens were evaluated in 27 patients with Chagasic cardiomyopathy (group I), 52 patients without evidence of cardiac dysfunction (group II), and 36 selected controls, either healthy patients or patients with other heart diseases (group III). The in vitro lymphoblastogenesis response to T. cruzi antigens was found to be high in groups I and II and low in group III. The mean stimulation index to T. cruzi antigens, in fact, tended to be highest in group I, suggesting a more intense immune response in patients with Chagasic cardiomyopathy. The proportion of individuals with reactivity to heart antigens was 28.6% in group I, 25% in group II, and 0% in group III. The finding of an equal percentage of reactivity to heart antigens in groups I and II was unexpected, as a higher incidence of positive reactions in group I was predicted. Consequently, it is thought that this finding and its relevance to the pathogenic process of Chagasic cardiomyopathy need to be carefully assessed in a longitudinal study.
对27例恰加斯性心肌病患者（第一组）、52例无心脏功能障碍证据的患者（第二组）以及36例选定的对照者（健康患者或患有其他心脏病的患者，第三组）进行了针对克氏锥虫抗原的反应性和针对心脏抗原的自身反应性评估。发现第一组和第二组对克氏锥虫抗原的体外淋巴细胞生成反应较高，而第三组较低。事实上，第一组对克氏锥虫抗原的平均刺激指数往往最高，这表明恰加斯性心肌病患者的免疫反应更强烈。第一组中对心脏抗原呈反应性的个体比例为28.6%，第二组为25%，第三组为0%。第一组和第二组中对心脏抗原呈反应性的个体比例相同，这一发现出乎意料，因为预计第一组的阳性反应发生率会更高。因此，人们认为这一发现及其与恰加斯性心肌病致病过程的相关性需要在纵向研究中仔细评估。
