磷脂酶相关穿透机制在立氏立克次体所致细胞损伤中的作用
Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii.
作者信息
Walker D H, Firth W T, Ballard J G, Hegarty B C
出版信息
Infect Immun. 1983 May;40(2):840-2. doi: 10.1128/iai.40.2.840-842.1983.
Abstract
The cholesterol receptor-binding drugs amphotericin B and digitonin reduced rickettsial plaque formation, presumably by blocking rickettsial attachment, even when added to the plaque model on day 4 post-inoculation when infected foci were well established. The phospholipase inhibitor phentermine reduced plaque formation, presumably by inhibiting the phospholipase-associated entry step of penetration.
摘要
胆固醇受体结合药物两性霉素B和洋地黄皂苷可减少立克次体蚀斑形成，推测是通过阻断立克次体的附着，即使在接种后第4天感染灶已充分形成时添加到蚀斑模型中也是如此。磷脂酶抑制剂芬特明可减少蚀斑形成，推测是通过抑制与磷脂酶相关的穿透进入步骤。
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