Villarejos V M, Visoná K A, Serra J
J Infect Dis. 1983 Apr;147(4):702-10. doi: 10.1093/infdis/147.4.702.
The specificity of a new antigen-antibody system (devised at the International Center for Medical Research and Training [ICMRT], San José, Costa Rica) for non-A, non-B (NANB) hepatitis was evaluated. ICMRT antigen was found in eight (21%) of 38 patients with acute NANB hepatitis; 22 patients (58%) seroconverted, including three who were positive for ICMRT antigen. Five patients with chronic NANB hepatitis were persistently positive for ICMRT antigen and negative for ICMRT antibody during several years of observation. Neither ICMRT antigen nor seroconversion was found among 11 patients with hepatitis A and 19 with hepatitis B occurring concomitantly with NANB hepatitis; only two of 56 patients with other liver diseases had ICMRT antigen, both presumably with chronic antigenemia. Seven of 128 household contacts of patients with NANB hepatitis had ICMRT antigen; 27 had antibody initially, and 35 (37% of susceptible contacts) seroconverted during the observation period. Less than 4% of household contacts of patients with hepatitis A or B seroconverted.
对一种新的抗原 - 抗体系统（由位于哥斯达黎加圣何塞的国际医学研究与培训中心[ICMRT]设计）针对非甲非乙型（NANB）肝炎的特异性进行了评估。在38例急性NANB肝炎患者中，有8例（21%）检测到ICMRT抗原；22例患者（58%）出现血清学转换，其中包括3例ICMRT抗原阳性患者。在数年的观察期内，5例慢性NANB肝炎患者的ICMRT抗原持续呈阳性，而ICMRT抗体呈阴性。在与NANB肝炎同时发生的11例甲型肝炎患者和19例乙型肝炎患者中，均未检测到ICMRT抗原和血清学转换；56例其他肝病患者中只有2例有ICMRT抗原，推测二者均患有慢性抗原血症。128例NANB肝炎患者的家庭接触者中有7例有ICMRT抗原；27例最初有抗体，35例（占易感接触者的37%）在观察期内出现血清学转换。甲型或乙型肝炎患者的家庭接触者中血清学转换的比例不到4%。
