Spertini O, Frei P C
Lancet. 1982 Oct 23;2(8304):899-90. doi: 10.1016/s0140-6736(82)90867-4.
26 patients with viral hepatitis were selected on the basis of negative responses to serological tests for hepatitis B virus and hepatitis A virus infections. The illness was acute in 19 patients and chronic persistent in the remaining 7. Immunodiffusion tests showed a single antigen-antibody system in the sera of all 26 patients. Each patient had at least one serum sample positive for antigen or antibody. In 1 post-transfusion case, the corresponding immunological marker was found in the donor. This system was considered specific for the disease, since the markers could not be detected in sera from patients with other liver conditions or immune complex diseases, or in sera from healthy blood donors without a history of hepatitis. The antigen could be separated from contaminating serum proteins. The purified preparation showed immunological identity with all our antigen-containing sera and with samples of a study already published. These results suggest the existence of an antigen associated with non-A, non-B, viral hepatitis and probably related to an infectious agent responsible for all the cases in this study.
根据对乙型肝炎病毒和甲型肝炎病毒感染血清学检测呈阴性反应的标准，选取了26例病毒性肝炎患者。其中19例为急性病，其余7例为慢性持续性疾病。免疫扩散试验显示，所有26例患者血清中均存在单一抗原抗体系统。每位患者至少有一份血清样本抗原或抗体呈阳性。在1例输血后病例中，在供血者体内发现了相应的免疫标志物。该系统被认为是该疾病所特有的，因为在其他肝脏疾病或免疫复合物疾病患者的血清中，或在无肝炎病史的健康献血者的血清中均未检测到这些标志物。抗原可从污染的血清蛋白中分离出来。纯化制剂与我们所有含抗原的血清以及已发表研究的样本显示出免疫同一性。这些结果表明存在一种与非甲非乙型病毒性肝炎相关的抗原，可能与导致本研究中所有病例的感染因子有关。
