Franz K A, Reubi F C
Kidney Int. 1983 Mar;23(3):526-9. doi: 10.1038/ki.1983.51.
Renal function was evaluated in 44 patients with adult polycystic renal disease at different stages of the affection. In 38 patients single or serial determinations of the glomerular filtration rate and the effective renal plasma flow were performed. In 21 of these patients and in an additional group of six subjects, serial determinations of serum creatinine were obtained. The data show that renal function does not decrease at a constant rate between birth and endstage renal failure. It remains well preserved for many years but decreases rapidly at a later stage. The relationship between indices of renal function (glomerular filtration rate, PAH-clearance and/or reciprocal serum creatinine) and the age of the patients might be described adequately by assuming that the impairment in renal function is proportional to the growth of the cysts and that the radius of the cysts increase at a slow but constant rate. Possible contributory factors are secondary infection and hypertension.
对44例处于不同病情阶段的成人多囊肾病患者的肾功能进行了评估。对38例患者进行了肾小球滤过率和有效肾血浆流量的单次或系列测定。在其中21例患者以及另外6例受试者中，进行了血清肌酐的系列测定。数据表明，从出生到终末期肾衰竭，肾功能并非以恒定速率下降。它在许多年内保持良好，但在后期会迅速下降。假设肾功能损害与囊肿生长成正比，且囊肿半径以缓慢但恒定的速率增加，那么肾功能指标（肾小球滤过率、对氨基马尿酸清除率和/或血清肌酐倒数）与患者年龄之间的关系可能会得到充分描述。可能的促成因素是继发感染和高血压。
