Weinstein T, Hwang D, Lev-Ran A, Ori Y, Korzets A, Levi J
Department of Nephrology, Rabin Medical Center-Golda (Hasharon) Campus, Petah-Tikva.
Isr J Med Sci. 1997 Oct;33(10):641-2.
In chronic renal failure, epidermal growth factor (EGF) excretion is decreased. In this study, asymptomatic adult polycystic kidney disease (APKD) patients with a relatively preserved glomerular filtration rate were examined. Excretion of EGF was studied in 6 patients with APKD (median age 42 years; serum creatinine [median] 95 [range-80-133] mumol/l) and compared with that of 28 healthy controls. EGF was determined in a spot morning urine by using a specific radioimmunoassay, and expressed in relation to creatinine excretion. Excretion of EGF in APKD was (median) 157 (range-13-359) and in the controls (median) 546 (range-238-1199) pmol/mmol creatinine (p < 0.001). Low excretion of EGF in APKD patients with preserved kidney function suggests a distal abnormality at an early stage of the disease, prior to the development of renal failure.
在慢性肾衰竭中，表皮生长因子（EGF）排泄减少。在本研究中，对肾小球滤过率相对保留的无症状成年多囊肾病（APKD）患者进行了检查。研究了6例APKD患者（中位年龄42岁；血清肌酐[中位值]95[范围-80-133]μmol/L）的EGF排泄情况，并与28例健康对照者进行比较。通过使用特定的放射免疫测定法在晨尿样本中测定EGF，并根据肌酐排泄量进行表达。APKD患者的EGF排泄量为（中位值）157（范围-13-359），而对照组为（中位值）546（范围-238-1199）pmol/mmol肌酐（p<0.001）。肾功能保留的APKD患者中EGF排泄量低表明在疾病早期、肾衰竭发生之前存在远端异常。
