Sakai K, Mizusawa H, Sakanashi M, Sakamoto K, Takeo S, Takenaka F
Nihon Yakurigaku Zasshi. 1978 Jan;74(1):37-47. doi: 10.1254/fpj.74.37.
In isolated dog heart, Theo-Esberiven 0.1 mg, which contains 12 mg proxyphylline, 2.5 mg rutin and 5 mg Melilotus extract, and proxyphylline (12 mg) increased coronary blood flow (CBF) and was associated with increased heart rate (HR) and myocardial contractile force (MCF). The effect of Theo-Esberiven on CBF was about 1.7 times higher than that of proxyphylline. Theo-Esberiven did not significantly affect myocardial oxygen consumption (QO2) and redox potential (deltaEh), while proxyphylline aggravated myocardial metabolisms, as determined from these parameters. Esberiven 0.1 ml, which contains 2.5 mg rutin and 5 mg Melilotus extract, slightly but signficantly increased CBF and decreased QO2 and deltaEh without changing HR and MCF. In situ, intra-coronary injection of either Theo-Esberiven or proxyphylline resulted in a dose-dependent increase in left circumflex coronary flow (LCCF). The effect of Esberiven on LCCF was much less and was slight at the higher doses. Intravenous injection of Theo-Esberiven (0.1 ml/kg) increased LCCF. Besides this change, marked fall in blood pressure and tachycardia were induced by both Theo-Esberiven and proxyphylline without the change in dP/dtmax. Esberiven by the same route led to the decrease in blood pressure associated with HR and dP/dtmax. These results indicate that Theo-Esberiven may be appropriately prescribed for ischemic heart diseases.
在离体犬心脏实验中，含12毫克丙羟茶碱、2.5毫克芦丁和5毫克草木犀提取物的茶喘平0.1毫克以及丙羟茶碱（12毫克）可增加冠脉血流量（CBF），并伴有心率（HR）加快和心肌收缩力（MCF）增强。茶喘平对CBF的作用比丙羟茶碱高约1.7倍。茶喘平对心肌耗氧量（QO2）和氧化还原电位（deltaEh）无显著影响，而丙羟茶碱从这些参数来看会加重心肌代谢。含2.5毫克芦丁和5毫克草木犀提取物的草木犀流浸膏0.1毫升可轻微但显著增加CBF，并降低QO2和deltaEh，而不改变HR和MCF。在原位实验中，冠脉内注射茶喘平或丙羟茶碱均可使左旋冠脉血流量（LCCF）呈剂量依赖性增加。草木犀流浸膏对LCCF的作用小得多，且在高剂量时作用轻微。静脉注射茶喘平（0.1毫升/千克）可增加LCCF。除此之外，茶喘平和丙羟茶碱均可引起血压显著下降和心动过速，而dP/dtmax无变化。通过相同途径给药的草木犀流浸膏可导致血压下降，并伴有HR和dP/dtmax降低。这些结果表明，茶喘平可能适用于治疗缺血性心脏病。
