Sakai K, Sakanashi M, Mizusawa H, Takenaka F, Takeshita S
Arch Int Pharmacodyn Ther. 1979 Nov;242(1):104-14.
Effects of Theo-Esberiven, a coronary vasodilator, on the development of collateral circulation were investigated in dogs with their left anterior descending artery chronically occluded. The drug was administered i.v. at 0.1 ml/kg once a day for 1 to 4 weeks after the occlusion. Left circumflex coronary flow in dogs treated with the drug was increased over the value in control ones when measured one week after the occlusion. At the same time, the ratio of retrograde pressure to perfusion pressure, which correlates negatively with the collateral vascular resistance, significantly exceeded the value in control (P less than 0.05). On the basis of observations with blood vessel casts of hearts, distinct anastomoses between the circumflex and anterior descending arteries had already been observed in all preparations from dogs treated for 2 weeks in contrast to the findings seen in control ones. There were less histological changes in myocardial tissue obtained from dogs treated for one week than those in control ones. From these results, Theo-Esberiven appears possibly to accerelate the collateral development at the earlier stages after the coronary occlusion.
研究了冠状动脉扩张剂茶喘平（Theo-Esberiven）对左前降支动脉长期闭塞犬侧支循环发育的影响。在闭塞后，每天静脉注射该药物0.1 ml/kg，持续1至4周。闭塞后一周测量时，接受该药物治疗的犬左旋冠状动脉血流量高于对照犬的值。同时，与侧支血管阻力呈负相关的逆行压力与灌注压力之比显著超过对照值（P小于0.05）。根据心脏血管铸型观察，与对照犬的结果相比，在接受治疗2周的犬的所有标本中，已观察到左旋支动脉与前降支动脉之间有明显的吻合。接受治疗一周的犬的心肌组织的组织学变化比对照犬少。从这些结果来看，茶喘平可能在冠状动脉闭塞后的早期阶段促进侧支循环的发育。
