由代谢活化的黄曲霉毒素B1诱导的碱基置换突变。
Base substitution mutations induced by metabolically activated aflatoxin B1.
作者信息
Foster P L, Eisenstadt E, Miller J H
出版信息
Proc Natl Acad Sci U S A. 1983 May;80(9):2695-8. doi: 10.1073/pnas.80.9.2695.
Abstract
We have determined the base substitutions generated by metabolically activated aflatoxin B1 in the lacI gene of a uvrB- strain of Escherichia coli. By monitoring over 70 different nonsense mutation sites, we show that activated aflatoxin B1 specifically induced GxC leads to TxA transversions. One possible pathway leading to this base change involves depurination at guanine residues. We consider this mechanism of mutagenesis in the light of our other findings that the carcinogens benzo[a]pyrene diol epoxide and N-acetoxyacetylaminofluorene also specifically induce GxC leads to TxA transversions.
摘要
我们已经确定了代谢活化的黄曲霉毒素B1在大肠杆菌uvrB-菌株的lacI基因中产生的碱基替换。通过监测70多个不同的无义突变位点，我们发现活化的黄曲霉毒素B1特异性诱导GxC到TxA的颠换。导致这种碱基变化的一种可能途径涉及鸟嘌呤残基的脱嘌呤作用。鉴于我们的其他发现，即致癌物苯并[a]芘二醇环氧化物和N-乙酰氧基乙酰氨基芴也特异性诱导GxC到TxA的颠换，我们考虑了这种诱变机制。
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