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右旋苯丙胺、氯氮卓和α-氟哌噻吨对大鼠强化选择和速率指标的不同影响。

Dissociable effects of d-amphetamine, chlordiazepoxide and alpha-flupenthixol on choice and rate measures of reinforcement in the rat.

作者信息

Evenden J L, Robbins T W

出版信息

Psychopharmacology (Berl). 1983;79(2-3):180-6. doi: 10.1007/BF00427808.

DOI:10.1007/BF00427808
PMID:6405426
Abstract

The role of reinforcers in influencing choice was studied by use of a schedule that included a random intermixing of reinforced and explicitly non-reinforced components. The just-reinforced response had a high likelihood of being repeated (win-stay), although there was no differential reinforcement for doing so, whereas responses just followed by explicit non-reinforcement had a very low probability of repetition (lose-stay). Non-parametric indices based on the theory of signal detection were used to derive a choice measure of reinforcement which was independent of alterations in average response rate. Treatments with d-amphetamine (0.2-4.5 mg/kg), chlordiazepoxide (0.25-16 mg/kg) and alpha-flupenthixol (0.03-0.6 mg/kg) showed that changes in the choice measure could be dissociated from changes in the response rate. These findings were supported by extinction and satiation tests.

摘要

通过使用一种包含强化和明确非强化成分随机混合的程序,研究了强化物在影响选择方面的作用。刚得到强化的反应有很高的重复可能性(赢则停留),尽管这样做并没有差别强化,而紧接着明确非强化的反应重复的概率非常低(输则停留)。基于信号检测理论的非参数指标被用于得出一种独立于平均反应率变化的强化选择测量方法。用右旋苯丙胺(0.2 - 4.5毫克/千克)、氯氮卓(0.25 - 16毫克/千克)和α-氟哌噻吨(0.03 - 0.6毫克/千克)进行的处理表明,选择测量的变化可以与反应率的变化区分开来。这些发现得到了消退和饱足测试的支持。

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本文引用的文献

1
Effects of random reinforcement sequences.随机强化序列的影响。
J Exp Anal Behav. 1974 Sep;22(2):301-10. doi: 10.1901/jeab.1974.22-301.
2
Studies on behavior. IV. Stimulant actions of methamphetamine.行为研究。IV. 甲基苯丙胺的兴奋作用。
J Pharmacol Exp Ther. 1958 Jan;122(1):137-47.
3
Pimozide-induced suppression of responding: evidence against a block of food reward.
Pharmacol Biochem Behav. 1980 Jun;12(6):917-23. doi: 10.1016/0091-3057(80)90453-0.
眶额叶或伏隔核多巴胺耗竭不影响大鼠基于风险的决策。
Cogn Affect Behav Neurosci. 2015 Sep;15(3):507-22. doi: 10.3758/s13415-015-0353-8.
4
Kids, candy, brain and behavior: age differences in responses to candy gains and losses.儿童、糖果、大脑与行为:对糖果得失反应的年龄差异
Dev Cogn Neurosci. 2014 Jul;9:82-92. doi: 10.1016/j.dcn.2014.01.005. Epub 2014 Jan 28.
5
Sex differences in response to amphetamine in adult Long-Evans rats performing a delay-discounting task.成年Long-Evans大鼠在执行延迟折扣任务时对苯丙胺反应的性别差异。
Pharmacol Biochem Behav. 2014 Mar;118:1-9. doi: 10.1016/j.pbb.2013.12.021. Epub 2013 Dec 31.
6
Dopamine modulates reward-related vigor.多巴胺调节与奖励相关的活力。
Neuropsychopharmacology. 2013 Jul;38(8):1495-503. doi: 10.1038/npp.2013.48. Epub 2013 Feb 18.
7
The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond.努力相关选择行为的行为药理学:多巴胺、腺苷及其他。
J Exp Anal Behav. 2012 Jan;97(1):125-46. doi: 10.1901/jeab.2012.97-125.
8
Dopamine receptor blockade attenuates the general incentive motivational effects of noncontingently delivered rewards and reward-paired cues without affecting their ability to bias action selection.多巴胺受体阻断减弱了非关联呈现的奖赏和与奖赏关联的线索的一般激励动机效应,而不影响它们影响行为选择的能力。
Neuropsychopharmacology. 2012 Jan;37(2):508-19. doi: 10.1038/npp.2011.217. Epub 2011 Sep 14.
9
Methylphenidate and fluphenazine, but not amphetamine, differentially affect impulsive choice in spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rats.哌醋甲酯和氟奋乃静,但不是安非他命,可不同程度地影响自发性高血压、Wistar-Kyoto 和 Sprague-Dawley 大鼠的冲动选择。
Brain Res. 2011 Jun 17;1396:45-53. doi: 10.1016/j.brainres.2011.04.040. Epub 2011 May 1.
10
Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits.伏隔核多巴胺及相关前脑回路的努力相关功能。
Psychopharmacology (Berl). 2007 Apr;191(3):461-82. doi: 10.1007/s00213-006-0668-9. Epub 2007 Jan 16.
4
Diazepam-induced eating and lever pressing for food in sated rats.
J Comp Physiol Psychol. 1974 May;86(5):930-41. doi: 10.1037/h0036404.
5
Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food.大鼠中抗精神病药物诱发的“快感缺失”:匹莫齐特阻断食物的奖赏特性。
Science. 1978 Jul 21;201(4352):262-4. doi: 10.1126/science.566469.
6
Decreased resistance to extinction after haloperidol: implications for the role of dopamine in reinforcement.氟哌啶醇治疗后消退抵抗性降低:对多巴胺在强化作用中角色的启示
Pharmacol Biochem Behav. 1979 May;10(5):751-60. doi: 10.1016/0091-3057(79)90328-9.
7
Effects of dopamine receptor blockade on alimentary behaviors: home cage food consumption, magazine training, operant acquisition, and performance.多巴胺受体阻断对摄食行为的影响:笼内食物消耗、条件反射训练、操作性习得及行为表现。
Psychopharmacology (Berl). 1979;66(3):219-25. doi: 10.1007/BF00428309.
8
Relationship between reward-enhancing and stereotypical effects of psychomotor stimulant drugs.
Nature. 1976 Nov 4;264(5581):57-9. doi: 10.1038/264057a0.