Königk E, Putfarken B
Tropenmed Parasitol. 1983 Mar;34(1):1-3.
Ornithine decarboxylase of P. falciparum, the initial and rate-limiting enzyme of the synthesis of polyamines, was inhibited by chloroquine when P. falciparum-infected red cells in culture were incubated in the presence of chloroquine for two hours. The degree of these inhibition produced by mefloquine was less. On the basis of these findings a sequence of reactions is discussed to define the mode of action of chloroquine. Additionally a preliminary investigation of the ornithine analogue, difluoromethylornithine, showed inhibitory effects on ornithine decarboxylase activity of P. falciparum.
恶性疟原虫的鸟氨酸脱羧酶是多胺合成的起始和限速酶，当在含有氯喹的条件下将培养的恶性疟原虫感染的红细胞孵育两小时后，该酶受到氯喹的抑制。甲氟喹产生的这种抑制程度较小。基于这些发现，讨论了一系列反应以确定氯喹的作用模式。此外，对鸟氨酸类似物二氟甲基鸟氨酸的初步研究表明，它对恶性疟原虫的鸟氨酸脱羧酶活性有抑制作用。
