• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on L1210 leukemia in mice.

作者信息

Prakash N J, Schechter P J, Grove J, Koch-Weser J

出版信息

Cancer Res. 1978 Sep;38(9):3059-62.

PMID:679213
Abstract
摘要

相似文献

1
Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on L1210 leukemia in mice.α-二氟甲基鸟氨酸(一种鸟氨酸脱羧酶的酶激活不可逆抑制剂)对小鼠L1210白血病的影响。
Cancer Res. 1978 Sep;38(9):3059-62.
2
Comparison of the biological effects of four irreversible inhibitors of ornithine decarboxylase in two murine lymphocytic leukemia cell lines.两种小鼠淋巴细胞白血病细胞系中四种鸟氨酸脱羧酶不可逆抑制剂的生物学效应比较
Cancer Res. 1986 Mar;46(3):1148-54.
3
Effects of methylglyoxal-bis(guanylhydrazone) on polyamine metabolism in spleens of mice with disseminated L1210 lymphoid leukemia.甲基乙二醛双(脒腙)对患有播散性L1210淋巴细胞白血病小鼠脾脏中多胺代谢的影响。
Cancer Res. 1974 Apr;34(4):886-92.
4
Inhibition of early embryogenic development in mice by alpha-difluoromethyl ornithine, an enzyme-activated irreversible inhibitor of L-ornithine decarboxylase [proceedings].α-二氟甲基鸟氨酸(一种L-鸟氨酸脱羧酶的酶激活不可逆抑制剂)对小鼠早期胚胎发育的抑制作用[会议论文集]
Br J Pharmacol. 1979 Jul;66(3):436P-437P.
5
Ornithine decarboxylase and polyamines in tissues of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase.新生大鼠组织中的鸟氨酸脱羧酶和多胺:鸟氨酸脱羧酶特异性不可逆抑制剂α-二氟甲基鸟氨酸的作用
J Pharmacol Exp Ther. 1982 Sep;222(3):741-5.
6
Independence of drug action on mitochondria and polyamines in L1210 leukemia cells treated with methylglyoxal-bis(guanylhydrazone).用甲基乙二醛双(脒腙)处理的L1210白血病细胞中药物作用对线粒体和多胺的独立性
Cancer Res. 1980 Dec;40(12):4533-40.
7
Further studies on difluoromethylornithine in African trypanosomes.关于二氟甲基鸟氨酸在非洲锥虫中的进一步研究。
Med Biol. 1981 Dec;59(5-6):434-40.
8
Antitumor properties of (2R,5R)-6-heptyne-2,5-diamine, a new potent enzyme-activated irreversible inhibitor of ornithine decarboxylase, in rodents.新型强效鸟氨酸脱羧酶酶激活不可逆抑制剂(2R,5R)-6-庚炔-2,5-二胺在啮齿动物中的抗肿瘤特性
Cancer Res. 1984 Nov;44(11):4972-7.
9
Independent regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in methylthioadenosine phosphorylase-deficient malignant murine lymphoblasts.甲硫腺苷磷酸化酶缺陷型恶性小鼠淋巴母细胞中鸟氨酸脱羧酶和S-腺苷甲硫氨酸脱羧酶的独立调节
Cancer Res. 1985 Aug;45(8):3567-72.
10
Methylglyoxal BIS (guanylhydrazone) and alpha-difluoromethylornithine-induced polyamine deprivation in psoriatic lesions.甲基乙二醛双(胍基腙)和α-二氟甲基鸟氨酸诱导银屑病皮损中的多胺缺乏。
Acta Derm Venereol. 1982;62(3):221-4.

引用本文的文献

1
Disrupting YAP1-mediated glutamine metabolism induces synthetic lethality alongside ODC1 inhibition in osteosarcoma.阻断 YAP1 介导的谷氨酰胺代谢联合 ODC1 抑制在骨肉瘤中诱导合成致死。
Cell Oncol (Dordr). 2024 Oct;47(5):1845-1861. doi: 10.1007/s13402-024-00967-1. Epub 2024 Aug 8.
2
One-Carbon and Polyamine Metabolism as Cancer Therapy Targets.一碳和多胺代谢作为癌症治疗靶点。
Biomolecules. 2022 Dec 19;12(12):1902. doi: 10.3390/biom12121902.
3
The role of polyamines in gastric cancer.多胺在胃癌中的作用。
Oncogene. 2021 Jul;40(26):4399-4412. doi: 10.1038/s41388-021-01862-x. Epub 2021 Jun 9.
4
Targeting the polyamine pathway-"a means" to overcome chemoresistance in triple-negative breast cancer.靶向多胺途径——克服三阴性乳腺癌化疗耐药性的“一种手段”。
J Biol Chem. 2020 May 8;295(19):6278-6279. doi: 10.1074/jbc.H120.013736.
5
Polyamines and cancer: implications for chemotherapy and chemoprevention.多胺与癌症:对化疗和化学预防的影响。
Expert Rev Mol Med. 2013 Feb 22;15:e3. doi: 10.1017/erm.2013.3.
6
Beneficial effects of a polyamine biosynthesis inhibitor on lupus in MRL-lpr/lpr mice.多胺生物合成抑制剂对MRL-lpr/lpr小鼠狼疮的有益作用。
Clin Exp Immunol. 1989 Nov;78(2):239-44.
7
alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin.α-二氟甲基鸟氨酸是鸟氨酸脱羧酶的不可逆抑制剂,可抑制肿瘤启动子诱导的小鼠皮肤多胺积累和致癌作用。
Proc Natl Acad Sci U S A. 1982 Oct;79(19):6028-32. doi: 10.1073/pnas.79.19.6028.
8
Effects of DL-alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, on the rat mammary tumour induced by 7,12-dimethylbenz[a]anthracene.鸟氨酸脱羧酶不可逆抑制剂DL-α-二氟甲基鸟氨酸对7,12-二甲基苯并[a]蒽诱导的大鼠乳腺肿瘤的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1982 Jul;320(1):72-7. doi: 10.1007/BF00499076.
9
Response of enzymes involved in the metabolism of polyamines to phytohaemagglutinin-induced activation of human lymphocytes.多胺代谢相关酶对植物血凝素诱导的人淋巴细胞激活的反应。
Biochem J. 1981 Jun 15;196(3):733-8. doi: 10.1042/bj1960733.
10
Regulation of S-adenosylmethionine decarboxylase by polyamines in Ehrlich ascites-carcinoma cells grown in culture.多胺对培养的艾氏腹水癌细胞中S-腺苷甲硫氨酸脱羧酶的调节作用
Biochem J. 1980 Sep 15;190(3):747-54. doi: 10.1042/bj1900747.