小鼠感染查巴迪疟原虫：氯喹和甲氟喹的作用。鸟氨酸脱羧酶活性的抑制
Plasmodium chabaudi-infection of mice: effects of chloroquine and mefloquine. Inhibition of ornithine decarboxylase activity.
作者信息
Königk E, Mirtsch S, Putfarken B, Abdel-Rasoul S
出版信息
Tropenmed Parasitol. 1981 Jun;32(2):73-6.
PMID:6973226
Abstract
Ornithine decarboxylase activity was inhibited in Plasmodium chabaudi-infected red cells of mice treated with chloroquine, mefloquine, primaquine and floxacrine. In vitro experiments on membrane-bound enzymes performed with intact P. chabaudi-infected red cells and corresponding ghost preparations showed a stimulation of NA+K+-ATP'ase and Ca2+Mg2+-ATP'ase activity in the presence of chloroquine, mefloquine and floxacrine.
摘要
在用氯喹、甲氟喹、伯氨喹和氟甲喹治疗的感染了查巴迪疟原虫的小鼠红细胞中，鸟氨酸脱羧酶活性受到抑制。用完整的感染了查巴迪疟原虫的红细胞和相应的血影制剂对膜结合酶进行的体外实验表明，在氯喹、甲氟喹和氟甲喹存在的情况下，钠钾-ATP酶和钙镁-ATP酶的活性受到刺激。
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