Abrams J
Am Heart J. 1983 May;105(5):848-54. doi: 10.1016/0002-8703(83)90251-x.
BN, a new nitrate formulation, has recently been made available. The main advantages of this medication is the combination of prompt onset of action, comparable to that of sublingual NTG, and sustained activity that persists for many hours. The tablet remains pharmacologically effective as long as it remains in the buccal pouch. A variety of studies indicate that BN is well tolerated by patients, acts promptly to provide protection against anginal pain, and has sustained efficacy that persists for 2 to 6 hours. Clinical investigations using serial treadmill testing in patients with angina demonstrate clinical effectiveness and bioactivity of BN beginning within minutes and lasting over 4 hours. The potential advantages of this preparation are discussed, and the formulation is compared to other available longacting nitrates. BN is an effective new addition to the nitrate armamentarium.
BN是一种新的硝酸盐制剂，最近已可供使用。这种药物的主要优点是起效迅速（与舌下含服硝酸甘油相当）且具有持续数小时的持续活性。只要片剂留在颊袋中，它就保持药理活性。各种研究表明，患者对BN耐受性良好，能迅速发挥作用以预防心绞痛，并且具有持续2至6小时的疗效。对心绞痛患者进行连续跑步机测试的临床研究表明，BN在数分钟内开始发挥临床疗效和生物活性，并持续超过4小时。本文讨论了这种制剂的潜在优点，并将其配方与其他现有的长效硝酸盐进行了比较。BN是硝酸盐类药物中的一种有效新药。
