Penketh A, Pitt T, Roberts D, Hodson M E, Batten J C
Am Rev Respir Dis. 1983 May;127(5):605-8. doi: 10.1164/arrd.1983.127.5.605.
Strains of Pseudomonas aeruginosa, isolated from the sputum of relatively fit patients with cystic fibrosis (CF) who had been recently colonized by the organism, showed typical cultural and serologic characteristics. The majority of strains of P. aeruginosa isolated from CF patients with chronic bronchopulmonary infection had 3 distinctive features, loss of 0 serotype reaction, expression of a new somatic antigen, and sensitivity to normal human serum. Patients with organisms with one or two of these features were more severely affected by the disease. The appearance of these variants may represent a critical stage in the progression of CF.
从近期被该病原体定植的相对健康的囊性纤维化（CF）患者痰液中分离出的铜绿假单胞菌菌株，表现出典型的培养和血清学特征。从患有慢性支气管肺部感染的CF患者中分离出的大多数铜绿假单胞菌菌株有3个显著特征，即O血清型反应丧失、新的菌体抗原表达以及对正常人血清敏感。具有其中一两个特征的病原体感染的患者受该疾病影响更为严重。这些变体的出现可能代表了CF进展中的一个关键阶段。
