Fenichel G M
Arch Neurol. 1983 May;40(5):261-6. doi: 10.1001/archneur.1983.04050050029002.
Many term newborns suffer some degree of perinatal asphyxia, but few become permanently brain damaged as a consequence, The newborns at risk for major neurologic handicaps have evidence of derangement in many organs, depressed cerebral function at birth that continues for days or weeks, and in many cases, convulsions soon after birth. The pathophysiologic mechanism of brain damage in hypoxic-ischemic encephalopathy remains contested, and no specific therapy is clearly beneficial. The immediate treatment of the asphyxiated term newborn requires attention to the derangements in multiple organ systems and the use of anticonvulsants when indicated.
许多足月儿会遭受一定程度的围产期窒息，但因此导致永久性脑损伤的却很少。有发生严重神经功能障碍风险的新生儿存在多器官功能紊乱的迹象，出生时脑功能就已减退，并持续数天或数周，而且在很多情况下，出生后不久就会出现惊厥。缺氧缺血性脑病中脑损伤的病理生理机制仍存在争议，尚无明确有效的特异性治疗方法。对窒息足月儿的紧急治疗需要关注多器官系统的功能紊乱，并在有指征时使用抗惊厥药物。
