Suhonen-Polvi H, Kero P, Korvenranta H, Ruotsalainen U, Haaparanta M, Bergman J, Simell O, Wegelius U
Department of Pediatrics, Turku University Central Hospital, Finland.
Eur J Nucl Med. 1993 Sep;20(9):759-65. doi: 10.1007/BF00180905.
Positron emission tomography (PET) permits the study of cerebral metabolism in vivo. We performed repeated PET studies with fluorine-18 fluorodeoxyglucose (FDG) as a tracer to measure cerebral glucose metabolism for estimation of neurological prognosis in infants with suspected hypoxic-ischaemic brain injury. Fourteen infants (gestational age 35.3 +/- 4.67 weeks) were examined during the neonatal period (at age 38.4 +/- 2.7 weeks) and again at the age of 3.5 +/- 0.7 months; one further infant was studied only once at the age of 2.5 months. All children also underwent ultrasound examinations. Electroencephalography and computed tomography or magnetic resonance imaging were performed according to their clinical condition and their neurological development has been followed. FDG accumulated most actively in the subcortical areas (thalami, brainstem and cerebellum) and the sensorimotor cortex during the neonatal period. The repeated PET study showed that the uptake of FDG was markedly high and increased in all brain sections of infants with normal development (n = 11), whereas those with delayed development (n = 4) had significantly lower values (P < or = 0.005).
正电子发射断层扫描（PET）可用于在体研究脑代谢。我们使用氟-18氟脱氧葡萄糖（FDG）作为示踪剂进行了多次PET研究，以测量脑葡萄糖代谢，从而评估疑似缺氧缺血性脑损伤婴儿的神经学预后。14名婴儿（胎龄35.3±4.67周）在新生儿期（年龄38.4±2.7周）接受了检查，并在3.5±0.7个月龄时再次接受检查；另有一名婴儿仅在2.5个月龄时接受了一次检查。所有儿童均接受了超声检查。根据其临床状况进行了脑电图和计算机断层扫描或磁共振成像检查，并对其神经发育情况进行了跟踪。在新生儿期，FDG在皮质下区域（丘脑、脑干和小脑）以及感觉运动皮质中最活跃地积聚。重复的PET研究表明，发育正常的婴儿（n = 11）所有脑区的FDG摄取明显较高且增加，而发育迟缓的婴儿（n = 4）的值则显著较低（P≤0.005）。
