Margalioth E J, Laufer N, Persistz E, Gaulayev B, Shemesh A, Schenker J G
Fertil Steril. 1983 Jun;39(6):841-4. doi: 10.1016/s0015-0282(16)47127-x.
Forty-seven oligoasthenospermic patients were treated with human chorionic gonadotropin, 5000 IU twice weekly for 12 to 15 weeks. Only three patients impregnated their wives following treatment. Sperm concentration subsequent to treatment decreased in 26 patients, increasing in only 8 cases. Sperm motility improved in 36% of the patients and deteriorated in 30%. During treatment, mean testosterone levels rose by 72%, mean estradiol levels rose by 140%, and mean follicle-stimulating hormone levels decreased by 80%. Mean prolactin levels remained unaltered. The disappointing results with human chorionic gonadotropin treatment fail to make it a recommendable therapy for patients with idiopathic oligoasthenospermia.
47名少弱精子症患者接受了人绒毛膜促性腺激素治疗，每周两次，每次5000国际单位，持续12至15周。治疗后只有3名患者使妻子受孕。治疗后26名患者的精子浓度下降，只有8例上升。36%的患者精子活力改善，30%恶化。治疗期间，平均睾酮水平上升72%，平均雌二醇水平上升140%，平均促卵泡激素水平下降80%。平均催乳素水平保持不变。人绒毛膜促性腺激素治疗令人失望的结果使其无法成为特发性少弱精子症患者的推荐疗法。
